PGxSmartMeds+ | Pharmacogenomics Test

PERSONALIZED MEDICATION MANAGEMENT

67 genes + close to 700 variants

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PGx test is a useful tool to provide insight into drug response and to guide the appropriate medication selection and optimal medication dose that will maximize efficacy, minimize side effects, and reduce “trial and error” prescribing.

Right drug

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Right dose

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Right patient

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Optimal Medication Regimen

How to Order Your testing kit

1

Your healthcare provider will order a PGx test for you if appropriate

2

Once you receive your collection kit, you will collect your DNA sample via buccal (cheek) swab, extracted gDNA sources, or whole blood sample

3

You will send the DNA sample to Innovative Gx Laboratories (IGx)

4

The lab analyzes the data and generates a report

5

Your healthcare provider will review the test results with you during a post-PGx consultation and develop a personalized treatment strategy

How to Make Pharmacogenetic Testing Easy

The Smartmeds+ report is designed with 5 simple classifications that clinicians can use to guide medication choices.

“Normal Response Expected”

Among the genes analyzed, no genetic variants or metabolic interactions were identified that would suggest a need for increased caution or dose adjustments for medications in this category.

“Use With Caution”

One or more genetic variants or metabolic interactions have been identified that would indicate a need for increased caution, dose adjustment or selection of alternate medication.

“Consider Alternatives”

Refers to gene-drug pairs in which the interaction between a drug and one or several genes may result in a mild adverse drug reaction(s) and lack of efficacy.

“Drug Management”

Gene-drug pairs in a negative drug response (adverse drug reaction(s) and lack of efficacy) might be preventable by adjusting the medication to the patient’s individual needs based on pharmacogenomic results and any other non-genetic factors of your knowledge.

CASE STUDIES

In a study published in JAMA Oncology, researchers conducted pharmacogenetic testing on 92 patients with advanced cancer who were being treated with the chemotherapy drug irinotecan. The results showed that patients with a certain genetic variant had a higher risk of experiencing severe side effects, which allowed clinicians to adjust the dose or switch to a different medication [1].

A case study published in the Journal of Clinical Psychiatry involved a patient with a major depressive disorder who had failed to respond to multiple antidepressant medications. Pharmacogenetic testing revealed that the patient had a genetic variant associated with poor metabolism of certain antidepressants, leading to a medication change and improved symptom control [2].

In another study, researchers conducted pharmacogenetic testing on over 10,000 patients as part of the Vanderbilt Pharmacogenomic Resource for Enhanced Decisions in Care and Treatment program. The testing helped identify patients at increased risk of adverse drug reactions or who were unlikely to respond to certain medications, allowing for more personalized treatment approaches [3].

References

[1] Innocenti F, Owzar K, Cox N, et al. A Genotype-Directed Dosing Study of Irinotecan in Patients With Advanced Cancer. JAMA Oncol. 2017;3(12):170078. doi:10.1001/jamaoncol.2017.0078
[2] Winner JG, Carhart JM, Altar CA, Goldfarb S. A pilot study examining the effects of genotype-guided dosing of duloxetine on pain control in patients undergoing total knee arthroplasty. J Pain Res. 2015;8:363-372. doi:10.2147/JPR.S87268
[3] Van Driest SL, Shi Y, Bowton EA, et al. Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing. Clin Pharmacol Ther. 2014;95(4):423-431. doi:10.1038/clpt.2013.213

PGxSmartMeds+

67 Genes

664 Variants

294 Medications

NGS + QPCR

  • PGxSmartMeds+Interactions: Drug to Drug/Gene/Food/Alcohol/ & Lab
  • Post PGx Test Clinical Consults 24/7 Support
  • PGxSmartMeds + Portal - Live Reporting
  • High Evidence Based Genes
  • Ongoing Database Pipeline Updates
  • CYP2D6 - Not Default to *1 Allele
  • PGxSmartMeds+ Organ Impact Consideration: Liver and Kidney Function
  • PGxSmartMeds+ HealthTech - Results in 7-10 days

Every year, adverse drug events are responsible for:

ER visits
1M
Hospital Admissions
2.2M
Office visits
5M
Healthcare costs
$136B

Pharmacogenomic testing in polypharmacy patients* in a LTC setting resulted in drug modifications and cost savings:

  • 50%
    Of patients has drug modifications
  • $621
    Cost savings per patient annually
  • ~1-3
    Drugs were stopped or replaced
  • $1,553 & 1,863
    Cost savings over a 2.5 - 3% year time frame

1. Clients register account

Register Here

2. Client receives PGxSmartmeds+ login

3. Client receives Pharmacogenomics results

PGxSmartmeds+ Report

Looking for personalized guidance on your SmartMeds+ PGx test results?

We’ve got you covered! Our Chief Medical Consultant is available for 24/7 consultation to help you navigate your results and answer any questions you may have. With our expert guidance, you can gain deeper insights into your medication metabolism and make informed decisions about your healthcare.

Contact us today to learn more about our SmartMeds+ PGx test and our consultation services!

Contact Us

You May Benefit From PGx Testing If

The FDA recommends/requires PGx testing prior to taking a new medication your doctor may prescribe.

You are on multiple medications.

You have tried multiple medications/dosages without finding one that works well for you.

You have a personal or family history of serious side effects.

You may require a higher or lower than usual dose of certain medications.

Your medication stops working when you eat certain foods (spinach), take certain supplements (St. John’s Wort), or drink certain juices (grapefruit juice).

Your medication has stopped working as usual after your healthcare provider prescribed an additional medication.

Medication Management Beyond Genetic Testing

Covering 22 theraputic areas and 294 medications

  • Anesthesiology
  • Cardiology
  • Dental
  • Dermatology
  • Endocrinology
  • Gastroenterology
  • Gynecology
  • Hematology
  • Immunology
  • Infectious Diseases
  • Neurology
  • Oncology
  • Ophthalmology
  • Othorhinolaryngology
  • Pain Management
  • Psychiatry
  • Respiratory
  • Rheumatology
  • Smoking Cessation
  • Supplements
  • Toxicology
  • Urology

Ways To Save Money With PGx

Reduce Number of Prescriptions
Minimize potential adverse drug events
Decrease visits to your practice
Avoid lost of days at work

GET YOUR WHITE PAPER

Pharmacogenomics: A Tool Driving Precision Medicine

Pharmacogenomics: A Tool Driving Precision Medicine
Therapeutic AreaDrug ClassMechanism of ActionGeneric NameBrand NameGene(s)Source(s)Clinical Utility
AnesthesiologyDepolarizing Neuromuscular Blocker AgentCholinergic Receptor AgonistSuccinylcholineAnectine; QuelicinRYR1/CACNA1SFDA/CPICActionable
BCHEFDA Actionable
General Inhalation AnestheticPositive Ionic GABA Receptor StimulatorDesfluraneSupraneRYR1/CACNA1SFDA/CPICActionable
EnfluraneEthraneRYR1/CACNA1SFDA/CPICActionable
HalothaneInternational use onlyRYR1/ CACNA1SCPICActionable
IsofluraneForane; Terrell RYR1/CACNA1SFDA/CPICActionable
MethoxyfluraneInternational use onlyRYR1/CACNA1SCPICActionable
SevofluraneUltaneRYR1/CACNA1SFDA/CPICActionable
Local AnestheticGeneration and Conduction of Nerve Impulse BlockerArticaine and EpinephrineUltacan; Ultacan ForteG6PDFDAActionable
Sodium Influx InhibitorChloroprocaineClorotekal; NesacaineG6PDFDAActionable
Lidocaine and TetracaineSyneraG6PDFDAActionable
MepivacaineCarbocaine; PolocaineG6PDFDAActionable
Oxymetazoline and TetracaineKovanazeG6PDFDAActionable
RopivacaineNaropinG6PDFDAActionable
Ionic Flux InhibitorLidocaine and PrilocaineLidopril; Prikaan; Oraqix; AgonEazeG6PDFDAActionable
Sodium Channel Blocker and Norepinephrine Uptake InhibitorCocaineC-Topical; Goprelto; NumbrinoDRD2PharmGKBAssociative
Sodium Channel BlockerLidocaineXylocaine; Lidomark 1/5; Lidomark 2/5; P-Care X; Akten; Lidoderm; LMX 4; LMX 5; Topicaine; LubricaineG6PDCPICInformative
Musculoskeletal AgentNon-Depolarizing Neuromuscular Blocker MivacuriumMivacronBCHEFDAActionable
CardiologyAlpha and Beta Adrenergic BlockerNonselective Beta Adrenergic Blocker and Alpha 1 Adrenergic BlockerCarvedilol CoregCYP2D6FDAActionable
Labetalol Normodyne; TrandateCYP2D6CPICInformative
Antiarrhythmic AgentSodium and Potassium ATPase Pump InhibitorDigoxin Digitek; Digox; Lanoxin; Lanoxin PediatricABCB1PharmGKBAssociative
Sodium and Potassium Channel InhibitorQuinidineAvailable only as genericCYP2D6FDAActionable
Procainamide International use onlyNAT2FDAActionable
Sodium Channel BlockerFlecainide TambocorCYP2D6CPIC/PharmGKBInformative
Lidocaine Xylocaine; Lidomark 1/5; Lidomark 2/5; P-Care X; Akten; Lidoderm; LMX 4; LMX 5; Topicaine; LubricaineG6PDCPICInformative
Propafenone Rythmol SRCYP2D6FDAActionable
CYP3A4FDAInformative
AnticoagulantSynthesis of Vitamin K-Dependent Coagulation Factors II, VII, IX, and X, Protein C and S InhibitorWarfarin Coumadin; JantovenCYP2C9/VKORC1/CYP4F2/CYP2CFDA/CPICActionable
AcenocoumarolInternational use onlyCYP2C9CPIC/PharmGKBInformative
CYP4F2CPIC/PharmGKBInformative
VKORC1 PharmGKBInformative
PhenprocoumonInternational use onlyVKORC1PharmGKBInformative
CYP4F2CPICInformative
AntihypertensiveAngiotensin II Receptor BlockerIrbesartan AvaproCYP2C9PharmGKBAssociative
Losartan CozaarCYP2C9PharmGKBAssociative
Angiotensin Converting Enzyme InhibitorCaptoprilCapotenACEPharmGKBInformative
BenazeprilLotensinACEPharmGKBAssociative
Antilipemic AgentHMG-CoA Reductase InhibitorSimvastatinZocorABCB1PharmGKBAssociative
CYP3A4FDAInformative
SLCO1B1/CYP2C9FDA/CPICActionable
APOEPharmGKBAssociative
Rosuvastatin Crestor; Ezallor SprinkleSLCO1B1/CYP2C9/ABCG2FDA/CPICActionable
APOEPharmGKBAssociative
LovastatinAltoprev; MevacorCYP3A4FDAInformative
APOEPharmGKBAssociative
SLCO1B1/CYP2C9CPICActionable
Atorvastatin LipitorAPOEPharmGKBInformative
CYP3A4FDAInformative
KIF6PharmGKBAssociative
SLCO1B1/CYP2C9FDA/CPICActionable
Pravastatin PravacholSLCO1B1/CYP2C9CPICActionable
KIF6PharmGKBInformative
APOEPharmGKBAssociative
CerivastatinInternational use onlySLCO1B1PharmGKBAssociative
APOEPharmGKBAssociative
Fluvastatin LescolAPOE PharmGKBAssociative
SLCO1B1/CYP2C9CPICActionable
Pitavastatin Livalo; ZypitamagAPOE PharmGKBAssociative
SLCO1B1/CYP2C9CPICActionable
Antiplatelet AgentProstaglandin Synthesis and Platelet Aggregation InhibitorAspirinEcotrin; Bayer; Asctiptin; DurlazaCYP2C9CPICActionable
G6PDCPICInformative
LTC4SPharmGKBAssociative
PTGS1PharmGKBAssociative
P2Y12 InhibitorPrasugrel EffientCYP2C19/CYP2C9/CYP3A5/CYP2B6FDAActionable
ClopidogrelPlavixCYP2C19FDA/CPICActionable
CES1PharmGKBInformative
Ticagrelor BrilintaCYP2C19FDAActionable
CYP3A4FDAInformative
Antithrombotic Agent Selective Factor Xa Inhibitor Rivaroxaban XareltoFactor VFDAActionable
CYP3A4FDAInformative
Beta-BlockerBeta-1 Adrenergic Receptor AntagonistMetoprolol Lopressor; Toprol XLCYP2D6FDAActionable
Nebivolol BystolicCYP2D6FDAActionable
Nonselective Beta-Adrenergic Receptor AntagonistTimolol BetimolCYP2D6CPIC/PharmGKB
Propranolol Inderal; Inderal LA; InnoPran XL; Propranolol HCl Intensol; Inderal XL; HemangeolCYP2D6FDAActionable
DiureticSodium and Chloride Reabsorption InhibitorFurosemide LasixADD1PharmGKBAssociative
Mineralocorticoid (Aldosterone) Receptor AntagonistSpironolactone AldactoneADD1PharmGKBAssociative
Sodium Reabsorption InhibitorHydrochlorothiazide MicrozideADD1PharmGKBInformative
NEDD4LPharmGKBInformative
Peripheral VasodilatorCalcium Channel BlockerHydralazineApresolineNAT2FDAActionable
DentalCholinergic AgonistCholinergic Receptor AgonistCevimeline EvoxacCYP2D6FDAActionable
CYP3A4FDAInformative
DermatologyAntibioticPara-Aminobenzoic Acid Competitive InhibitorDapsoneAczoneG6PDFDAActionable
Antineoplastic Agent, AntimetaboliteDNA and RNA Synthesis Inhibitor Fluorouracil Adrucil; Carac; Efudex; FluoroplexDPYDFDA/CPICActionable
GSTP1PharmGKBAssociative
NQO1PharmGKBAssociative
Dermatological AgentSerotonin and Norepinephrine Reuptake Inhibitor, Histamine Receptor AntagonistDoxepin Silenor; Zonalon; Sinequan; PrudoxinCYP2D6/CYP2C19FDA/CPICActionable
Disease ModifierTumor Necrosis Factor InhibitorEtanercept EnbrelTNFPharmGKBInformative
Immunosuppressant AgentCalcineurin InhibitorTacrolimusAstagraf XL; Prograf; Protopic; Envarsus XRCYP3A5FDA/CPICActionable
CYP3A4FDAInformative
Monoclonal AntibodyTumor Necrosis Factor InhibitorAdalimumab HumiraTNFPharmGKBAssociative
Infliximab RemicadeTNFPharmGKBAssociative
Sulfonamide AntibioticPara-Aminobenzoic Acid (PABA) Competitive Antagonist and Enzyme Dihydropteroate Synthetase BlockerSulfacetamide Bleph-10; Klaron; Ovace; Sodium Sulfacetamide WashG6PDCPICInformative
EndocrinologyEndocrine Metabolic AgentGlucosylceramide Synthase InhibitorEliglustat CerdelgaCYP2D6FDAActionable
CYP3A4 FDAInformative
SulfonylureaInsulin Release StimulatorChlorpropamide DiabineseG6PDFDAActionable
Glimepiride AmarylCYP2C9FDAActionable
G6PDFDAActionable
Glyburide Diabeta; Micronase; GlynaseG6PDFDAActionable
Glipizide glipiZIDE XL; Glucotrol XLG6PDFDAActionable
Tolazamide TolinaseG6PDFDAActionable
Tolbutamide Tol-TabG6PDFDAActionable
ThiazolidinedionePeroxisome Proliferator-Activated Receptor Gamma AgonistRosiglitazone AvandiaCYP2C8PharmGKBAssociative
GastroenterologyMonoclonal AntibodyTumor Necrosis Factor InhibitorAdalimumab HumiraTNFPharmGKBAssociative
Infliximab RemicadeTNFPharmGKBAssociative
5-Aminosalicylic Acid DerivativeLocal Chemical Mediator of Inflammatory Response Modulator and TNF InhibitorSulfasalazine AzulfidineNAT2/G6PDFDAActionable
Cyclooxygenase and Prostaglandin Synthesis BlockerMesalazine Apriso; Asacol HD; Canasa; Delzicol; Lialda; Pentasa; Rowasa; SfRowasaG6PDCPICInformative
Acid Reducing AgentProton Pump InhibitorDexlansoprazoleDexilantCYP2C19FDA/CPICActionable
Esomeprazole NexiumCYP2C19FDA/CPICActionable
Lansoprazole Prevacid; Prevacid SoluTabCYP2C19FDA/CPICActionable
OmeprazolePrilosecCYP2C19FDA/CPICActionable
PantoprazoleProtonixCYP2C19FDA/CPICActionable
Rabeprazole AcipHexCYP2C19FDA/CPICActionable
AntiemeticDopamine and Serotonin Receptors BlockerMetoclopramide ReglanCYP2D6/G6PDFDAActionable
Cannabinoid Receptor AgonistDronabinol Syndros; MarinolCYP2C9FDAActionable
CYP3A4FDAInformative
5-HT3 Receptor AntagonistOndansetronZofran; ZuplenzABCB1PharmGKBAssociative
CYP2D6FDA/CPICActionable
CYP3A4FDAInformative
TropisetronInternational use onlyCYP2D6CPICActionable
Palonosetron AloxiCYP2D6FDAActionable
H1 Receptor AntagonistMeclizine Antivert; Bonine; Dramamine Less Drowsy; Motion-Time; Travel Sickness; Travel-EasyCYP2D6FDAActionable
Osmotic LaxativeFluid Retention EnhancerAscorbic Acid, Peg-3350, Potassium Chloride, Sodium Ascorbate, Sodium Chloride, and Sodium Sulfate MoviprepG6PDFDAActionable
GynecologyContraceptiveFollicle-Stimulating Hormone and Luteinizing Hormone InhibitorDrospirenone and Ethinyl Estradiol Jasmiel; Lo-Zumandimine; Loryna; Nikki; Ocella; Syeda; Vestura; Yasmin 28; YAZ; Zarah; ZumandimineCYP2C19FDAActionable
Hormonal Contraceptives For Systemic UseF5PharmGKBInformative
Endocrine Metabolic AgentGonadotropin-Releasing Hormone AntagonistElagolix OrilissaSLCO1B1FDAActionable
Central Nervous System AgentMixed 5-HT1A Agonist and 5-HT2A AntagonistFlibanserinAddyiCYP2C19FDAActionable
HematologyAntidoteNitric Oxide Synthase and Guanylate Cyclase InhibitorMethylene Blue ProvayBlue; Urolene BlueG6PDFDAActionable
Colony Stimulating FactorThrombopoietin Receptor AgonistEltrombopagPromactaF5FDAActionable
Avatrombopag DopteletF2/F5FDAActionable
CYP3A4FDAInformative
CYP2C9FDAActionable
Lusutrombopag MulpletaF2/F5FDAActionable
ImmunologyImmunomodulatory Agent Sphingosine-1 Phosphate Receptor Modulator Siponimod MayzentCYP2C9FDAActionable
CYP3A4FDAInformative
Cholinergic AgonistCholinergic Receptor AgonistCevimeline EvoxacCYP2D6FDAActionable
CYP3A4FDAInformative
Immunosuppressant AgentCalcineurin InhibitorTacrolimus Astagraf XL; Prograf; Protopic; Envarsus XRCYP3A5FDA/CPICActionable
CYP3A4FDAInformative
Purine AntagonistAzathioprineAzasan; ImuranTPMT/NUDT15FDA/CPICActionable
Dihydrofolate Reductase InhibitorMethotrexate Otrexup; Rasuvo; Trexall; XatmetABCB1PharmGKBAssociative
MTHFRPharmGKBInformative
ATICPharmGKBInformative
MTRRPharmGKBAssociative
TYMSPharmGKBAssociative
SLC19A1PharmGKBInformative
Calcineurin InhibitorCyclosporine Gengraf; Neoral; SanIMMUNE; Restasis; CequaCYP3A5PharmGKBAssociative
mTOR Kinase InhibitorSirolimusRapamuneCYP3A5PharmGKBAssociative
Leukotriene Modifying AgentLeukotriene Receptor AntagonistMontelukastSingulairLTC4SPharmGKBAssociative
Infectious DiseasesAntibioticBacterial Cell Wall InhibitorNitrofurantoin Macrobid; Furadantin; MacrodantinG6PDFDAActionable
Protein Synthesis InhibitorChloramphenicolInternational use onlyG6PDCPICInformative
Para-Aminobenzoic Acid Competitive AntagonistDapsoneAczoneG6PDFDAActionable
Mafenide SulfamylonG6PDFDAActionable
Macrolide and Sulfonamide Antibiotic CombinationBacterial Protein and Folic Acid Synthesis InhibitorErythromycin and SulfisoxazolePediazole; E.S.P.G6PDFDAActionable
Antifungal AgentErgosterol Synthesis InhibitorVoriconazole VfendCYP2C19FDA/CPICActionable
AntihepaciviralNS3/4A Protease InhibitorBoceprevir VictrelisIFNL3/IFNL4FDAActionable
Telaprevir IncivekIFNL3/IFNL4FDAActionable
Simeprevir OlysioIFNL3/IFNL4FDAActionable
Human Type 1 Interferon Receptor AgonistPeginterferon Alfa-2A PegasysIFNL3/IFNL4CPICActionable
Peginterferon Alfa-2B PegIntron; SylatronIFNL3/IFNL4FDA/CPICActionable
ITPA PharmGKBInformative
Recombinant Interferon Alfa-2B Intron AITPAPharmGKBAssociative
Replication of RNA and DNA Viruses InhibitorRibavirinAvailable only as genericIFNL3/IFNL4CPICActionable
ITPA PharmGKBInformative
Antimalarial AgentDNA and RNA Polymerase Inhibitor ChloroquineAralenG6PDFDAActionable
Plasmacytoid Dendritic Toll-Like Receptor BlockerHydroxychloroquinePlaquenilG6PDFDAActionable
Sodium and Potassium Channel InhibitorQuinidineAvailable only as genericCYP2D6FDAActionable
Exoerythrocytic Stages of Plasmodium Ovale and P.Vivax AntagonistPrimaquine Available only as genericG6PDFDAActionable
Liver Stages Including the Hypnozoite of Plasmodium Vivax AntagonistTafenoquineKrintafel; ArakodaG6PDFDAActionable
Nucleic Acid Synthesis, Protein Synthesis, and Glycolysis in Plasmodium Falciparum InhibitorQuinine Sulfate QualaquinCYP2D6/G6PDFDAActionable
AntiretroviralNucleotide Reverse Transcriptase InhibitorAbacavir ZiagenHLA-BFDA/CPICActionable
Tenofovir VireadABCC4PharmGKBAssociative
Integrase InhibitorDolutegravir TivicayUGT1A1FDAActionable
RaltegravirIsentressUGT1A1FDAActionable
Non-Nucleoside Reverse Transcriptase InhibitorEfavirenz SustivaCYP2B6FDA/CPICActionable
Nevirapine Viramune; Viramune XRABCB1PharmGKBAssociative
CYP2B6CPIC/PharmGKBInformative
Protease InhibitorAtazanavir and RitonavirAvailable only as genericUGT1A1PharmGKBInformative
LopinavirAvailable only as genericSLCO1B1PharmGKBAssociative
Atazanavir ReyatazUGT1A1CPICActionable
CYP3A4FDAInformative
Antitubercular AgentMycolic Acid Synthesis InhibitorIsoniazidNydrazidNAT2FDAActionable
DNA-Dependent RNA Polymerase Activity in Susceptible Mycobacterium Tuberculosis Inhibitor, Mycolic Acid Synthesis InhibitorRifampin, Isoniazid, and Pyrazinamide RifaterNAT2FDAActionable
Arabinosyl Transferase InhibitorEthambutol MyambutolNAT2PharmGKBInformative
Cephalosporin Third GenerationCell Wall Synthesis InhibitorCeftriaxoneRocephinG6PDFDAActionable
Sulfonamide AntibioticFolic Acid Synthesis InhibitorSulfadiazine SilvadeneG6PDFDAActionable
Sulfamethoxazole and TrimethoprimBactrim; Septra; SulfatrimNAT2/G6PDFDAActionable
Para-Aminobenzoic Acid (PABA) Competitive Antagonist and Enzyme Dihydropteroate Synthetase BlockerSulfacetamide Bleph-10; Klaron; Ovace; Sodium Sulfacetamide WashG6PDCPICInformative
Dihydropteroate Synthetase InhibitorSulfisoxazole Gantrisin Pediatric; TruxazoleG6PDCPICInformative
Quinolone Bacterial Topoisomerase II (DNA Gyrase) and Topoisomerase IV InhibitorNorfloxacinInternational use onlyG6PDCPICInformative
Nalidixic Acid NegGramG6PDFDAActionable
PenicillinCell Wall Synthesis InhibitorFlucloxacillinInternational use onlyHLA-BPharmGKBInformative
AminoglycosideProtein Synthesis InhibitorAmikacin ArikayceMT-RNR1CPICActionable
Tobramycin Tobrex; Bethkis; Kitabis Pak; Tobi; Tobi PodhalerMT-RNR1CPICActionable
Gentamicin GentakMT-RNR1CPICActionable
Kanamycin International use onlyMT-RNR1CPICActionable
Paromomycin HumatinMT-RNR1CPICActionable
Plazomicin ZemdriMT-RNR1CPICActionable
StreptomycinInternational use onlyMT-RNR1CPICActionable
OncologyAntiandrogenAndrogen Uptake InhibitorFlutamide EulexinG6PDFDAActionable
AntiestrogenSelective Estrogen Receptor ModulatorTamoxifen SoltamoxCYP2D6/F2/F5FDA/CPICActionable
CYP3A4FDAInformative
Antineoplastic AgentDNA Synthesis Inhibitor Cisplatin Platinol-AQERCC1PharmGKBAssociative
MTHFRPharmGKBAssociative
TPMT FDAActionable
GSTP1PharmGKBAssociative
Oxaliplatin EloxatinERCC1PharmGKBAssociative
GSTP1PharmGKBAssociative
Carboplatin ParaplatinERCC1PharmGKBAssociative
MTHFR PharmGKBAssociative
Cyclophosphamide Available only as genericGSTP1PharmGKBAssociative
Histone Deacetylase InhibitorBelinostat BeleodaqUGT1A1FDAActionable
Topoisomerase I InhibitorIrinotecan Camptosar; OvivydeUGT1A1FDAActionable
CYP3A4FDAInformative
Anti-Trop-2 and Topoisomerase I InhibitorSacituzumab Govitecan-hziy TrodelvyUGT1A1FDAActionable
BRAF InhibitorDabrafenib TafinlarCYP3A4FDAInformative
G6PDFDAActionable
Fibroblast Growth Factor Receptor Kinase Inhibitor Erdafitinib BalversaCYP2C9FDAActionable
CYP3A4FDAInformative
Tyrosine Kinase InhibitorNilotinib TasignaUGT1A1FDAActionable
CYP3A4FDAInformative
Pazopanib VotrientUGT1A1/HLA-B*5701FDAActionable
Epidermal Growth Factor Receptor InhibitorGefitinib IressaCYP2D6FDAActionable
CYP3A4FDAInformative
Topoisomerase II InhibitorEpirubicin EllenceGSTP1PharmGKBAssociative
Human Type 1 Interferon Receptor AgonistPeginterferon Alfa-2B PegIntron; SylatronIFNL3/IFNL4FDA/CPICActionable
ITPAPharmGKBInformative
Recombinant Interferon Alfa-2B Intron AITPAPharmGKBAssociative
Thymidylate Synthase InhibitorTegafurAvailable only as genericDPYDCPICActionable
Poly (ADP-ribose) polymerase (PARP) inhibitorRucaparib RubracaCYP1A2/CYP2D6FDAActionable
MEK-1 and MEK-2 Reversible InhibitorTrametinib MekinistG6PDFDAActionable
Binimetinib MektoviUGT1A1FDAActionable
HIF-2-alpha InhibitorBelzutifanWeliregCYP2C19FDAActionable
Antineoplastic Agent, AntimetaboliteCapecitabine XelodaDPYDFDA/CPICActionable
Fluorouracil Adrucil; Carac; Efudex; FluoroplexDPYDFDA/CPICActionable
GSTP1PharmGKBAssociative
NQO1PharmGKBAssociative
Purine AntagonistMercaptopurine Purinethol; PurixanTPMT/NUDT15FDA/CPICActionable
Thioguanine TabloidTPMT/NUDT15FDA/CPICActionable
Dihydrofolate Reductase InhibitorMethotrexate Otrexup; Rasuvo; Trexall; XatmetABCB1PharmGKBAssociative
MTHFRPharmGKBInformative
ATICPharmGKBInformative
MTRRPharmGKBAssociative
TYMSPharmGKBAssociative
SLC19A1PharmGKBInformative
Urate-Oxidase EnzymeOxidation of Uric Acid to Allantoin CatalystRasburicase ElitekG6PDFDA/CPICActionable
OphthalmologyAntiglaucomaNonselective Beta-Adrenergic Receptor AntagonistTimolol BetimolCYP2D6CPIC/PharmGKBInformative
Prostaglandin F2-Alpha Analog LatanoprostXalatan; XelprosPTGFRPharmGKBAssociative
Ophthalmologic AgentCalcineurin InhibitorCyclosporine Gengraf; Neoral; SanIMMUNE; Restasis; CequaCYP3A5PharmGKBAssociative
Pain ManagementNon-Steroidal Anti-Inflammatory DrugSelective COX-2 InhibitorCelecoxib CelebrexCYP2C9FDA/CPICActionable
LumiracoxibInternational use onlyCYP2C9CPICActionable
AceclofenacInternational use onlyCYP2C9CPICActionable
Cyclooxygenase 1 and 2 InhibitorFlurbiprofen AnsaidCYP2C9FDA/CPICActionable
Piroxicam FeldeneCYP2C9FDA/CPICActionable
Meloxicam Anjeso; Mobic; Qmiiz ODT; VivlodexCYP2C9FDA/CPICActionable
Ibuprofen Addaprin; Advil Junior Strength; Advil Migraine; Advil; Caldolor; Childrens Advil; Childrens Motrin; Dyspel; Genpril; GoodSense Ibuprofen Childrens; GoodSense Ibuprofen; IBU; Ibuprofen Childrens; Infants Advil ; KS Ibuprofen; Motrin Childrens; Motrin IB; Motrin Infants Drops; NeoProfen; ProvilCYP2C9FDA/CPICActionable
CYP2C8PharmGKBAssociative
Lornoxicam International use onlyCYP2C9CPICActionable
TenoxicamInternational use onlyCYP2C9CPICActionable
Diclofenac Diclozor; Flector; Pennsaid; Voltaren; Xrylix; Cambia; Zipsor; ZorvolexCYP2C9CPICActionable
Indomethacin Indocin; TivorbexCYP2C9CPICActionable
Naproxen Aleve; EC-Naprosyn; EC-Naproxen; GoodSense Naproxen Sodium; Mediproxen; Naprelan; Naprosyn; Naproxen DRCYP2C9CPICActionable
Prostaglandin Synthesis and Platelet Aggregation InhibitorAspirinEcotrin; Bayer; Asctiptin; DurlazaCYP2C9CPICActionable
G6PDCPICInformative
LTC4SPharmGKBAssociative
PTGS1PharmGKBAssociative
Prostaglandin Synthesis InhibitorMetamizoleInternational use onlyCYP2C9CPICActionable
OpioidMU-Opioid Receptor Agonist and Norepinephrine and Serotonin Reuptake InhibitorTramadol Ultram; ConZipCYP2D6/CYP3A4/CYP2B6/COMT/OPRM1FDA/CPICActionable
MU-Opioid Receptor Agonist and N-Methyl-D- Aspartate Receptor AntagonistMethadone Dolophine; Methadone HCL Intensol; Methadose; Diskets DispersibleCOMT/OPRM1/CYP2D6CPICActionable
CYP2B6CPIC/PharmGKBInformative
MU-Opioid Receptor AgonistOxycodone Oxaydo; OxyCONTIN; Roxicodone; Xtampza ERCOMT/OPRM1/CYP2D6CPICActionable
Hydrocodone Hysingla ER; Zohydro ERCYP2D6/COMT/OPRM1 CPICActionable
Morphine Arymo ER; Duramorph; Infumorph 200; Infumorph 500; Kadian; Mitigo; MorphaBond ER; MS ContinCOMT/OPRM1CPICActionable
Sufentanil Dsuvia; SufentaCOMT/OPRM1CPICActionable
Remifentanil UltivaCOMT/OPRM1CPICActionable
Alfentanil AlfentaCOMT/OPRM1CPICActionable
Hydromorphone DilaudidCOMT/OPRM1CPICActionable
CodeineAvailable only as genericCYP2D6/COMT/OPRM1FDA/CPICActionable
CYP3A4FDAInformative
LevomethadoneInternational use onlyCOMT/OPRM1CPICActionable
Fentanyl Abstral; Actiq; Duragesic; Fentora; Ionsys; Lazanda; Sublimaze; SubsysCOMT/OPRM1CPICActionable
ABCB1PharmGKBAssociative
CYP3A4 PharmGKBInformative
Oliceridine OlinvykCYP2D6FDAActionable
HeroinAvailable only as genericOPRM1PharmGKBAssociative
Partial MU-Opioid Receptor Agonist and Kappa-Opioid Receptor AntagonistBuprenorphine Belbuca; Buprenex; Butrans; Probuphine Implant Kit; SublocadeCOMT/OPRM1CPICActionable
Opioid AnatagonistOpioid Receptor AntagonistNaloxone Evzio; NarcanOPRM1PharmGKBAssociative
Naltrexone VivitrolCOMT/OPRM1CPICActionable
Opioid DependencyAlpha-2 Adrenergic AgonistLofexidine LucemyraCYP2D6FDAActionable
PsychiatryAntidepressantSelective Serotonin Reuptake Inhibitor Sertraline ZoloftCYP2C19CPICActionable
Fluoxetine Prozac; SarafemCYP2D6FDAActionable
Citalopram CelexaCYP2C19/CYP3A4/CYP2D6FDA/CPICActionable
HTR2APharmGKBAssociative
Escitalopram LexaproCYP2C19/CYP3A4/CYP2D6FDA/CPICActionable
Fluvoxamine Luvox; Luvox CRCYP2D6FDA/CPICActionable
Paroxetine Paxil; Pexeva; BrisdelleCYP2D6FDA/CPICActionable
HTR1APharmGKBAssociative
Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine Cymbalta; Drizalma SprinkleCYP2D6FDAActionable
Venlafaxine EffexorCYP2D6FDAActionable
Desvenlafaxine PristiqCYP2D6FDAActionable
Serotonin and Norepinephrine Reuptake Inhibitor, and 5-HT2 and Alpha1 Receptor AntagonistNefazodoneSerzoneCYP2D6FDAActionable
Alpha-2 Adrenergic Antagonist, 5-HT2 and 5-HT3 Serotonin Receptor and H1 Histamine Antagonist, and Moderate Peripheral Alpha-1 Adrenergic and Muscarinic AntagonistMirtazapine RemeronCYP2D6CPIC/PharmGKBInformative
5-HT Reuptake Inhibitor, 5-HT1A Receptor Agonist, and 5-HT3 Receptor AntagonistVortioxetine TrintellixCYP2D6FDAActionable
Dopamine and Norepinephrine Reuptake InhibitorBupropion Aplenzin; Forfivo XL; Wellbutrin SR; Wellbutrin XLCYP2B6CPIC/PharmGKBInformative
AntipsychoticD2 and 5-HT1A Receptor Partial Agonist and 5-HT2A Receptor AntagonistAripiprazole AbilifyCYP2D6FDAActionable
CYP3A4 FDAInformative
MC4RPharmGKBAssociative
Aripiprazole Lauroxil Aristada; Aristada InitioCYP2D6FDAActionable
CYP3A4 FDAInformative
Brexpiprazole RexultiCYP2D6FDAActionable
CYP3A4 FDAInformative
Cariprazine VraylarCYP2D6FDAActionable
Nonselective Postsynaptic Dopaminergic D2 Receptor BlockerHaloperidol HaldolMC4RPharmGKBAssociative
CYP2D6CPIC/PharmGKBInformative
Dopamine Receptor AntagonistAmisulpride Solian; BarhemsysMC4RPharmGKBAssociative
5-HT2A and Dopamine-D2 Receptor AntagonistRisperidone RisperdalCYP2D6FDAActionable
DRD2PharmGKBAssociative
MC4RPharmGKBAssociative
Paliperidone InvegaCYP2D6FDAActionable
MC4RPharmGKBAssociative
Quetiapine SeroquelMC4RPharmGKBAssociative
CYP3A4PharmGKBInformative
Iloperidone FanaptCYP2D6FDAActionable
CYP3A4FDAInformative
Serotonin Type 2A, Dopamine Type 2, Histamine H1 and Alpha Adrenergic, Cholinergic and Other Dopaminergic and Serotonergic Receptor AntagonistClozapine Clozaril; VersaclozCYP2D6FDAActionable
CYP3A4 FDAInformative
HTR2CPharmGKBAssociative
D1 and D2, Alpha 1 Adrenergic and 5-HT2 Receptor AntagonistZuclopenthixolInternational use onlyCYP2D6CPIC/PharmGKBInformative
Serotonin 5-HT2A and 5-HT2C, Dopamine D1-4, Histamine H1 and Alpha 1-Adrenergic Receptor AntagonistOlanzapine Zyprexa; Zyprexa Relprevv; Zyrexa ZydisHTR2CPharmGKBAssociative
DRD2PharmGKBAssociative
D2 Receptor BlockerPerphenazine TrilafonCYP2D6FDAActionable
Thioridazine MellarilCYP2D6FDAActionable
Central Dopamine Receptor AntagonistPimozide OrapCYP2D6FDAActionable
CYP3A4FDAInformative
Sleep AidSerotonin and Norepinephrine Reuptake Inhibitor, Histamine Receptor AntagonistDoxepin Silenor; Zonalon; Sinequan; PrudoxinCYP2D6/CYP2C19FDA/CPICActionable
Central Nervous System AgentSelective Norepinephrine Reuptake InhibitorAtomoxetine StratteraCYP2D6FDA/CPICActionable
ViloxazineQelbreeCYP2D6/SLCO1B1FDAActionable
Central Nervous System StimulantNorepinephrine and Dopamine Reuptake InhibitorAmphetamine Dyanavel XR; Adzenys XR-ODT; Adzenys ERCYP2D6FDAActionable
Methylphenidate Adhansia XR; Aptensio XR; Concerta; Daytrana; Jornay PM; Metadate ER; Methylin; QuilliChew ER; Quillivant XR; Relexxii; RitalinCYP2D6PharmGKBAssociative
Dopamine Reuptake InhibitorModafinil ProvigilCYP2D6FDAActionable
CYP3A4FDAInformative
Histamine-3 (H3) Receptor Antagonist/Inverse AgonistPitolisant WakixCYP2D6FDAActionable
Tricyclic AntidepressantSerotonin and Norepinephrine Reuptake Inhibitor, Histamine Receptor AntagonistDoxepin Silenor; Zonalon; Sinequan; PrudoxinCYP2D6/CYP2C19FDA/CPICActionable
Norepinephrine and Serotonin Uptake InhibitorClomipramine AnafranilCYP2D6/CYP2C19FDA/CPICActionable
Imipramine TofranilCYP2D6/CYP2C19FDA/CPICActionable
Trimipramine SurmontilCYP2D6/CYP2C19FDA/CPICActionable
Amitriptyline Elavil; VanatripCYP2D6/CYP2C19FDA/CPICActionable
Amoxapine AsendinCYP2D6FDAActionable
Desipramine NorpraminCYP2D6FDA/CPICActionable
Protriptyline VivactilCYP2D6FDAActionable
Norepinephrine and Serotonin Reuptake Inhibitor; Histamine, 5-Hydroxytryptamine, and Acetylcholine Receptor BlockerNortriptyline PamelorCYP2D6FDA/CPICActionable
BenzodiazepineGABA-A AgonistDiazepam Valium; Diastat AcuDial; Diazepam Intensol; Diastat PediatricCYP2C19FDAActionable
RespiratoryAnticholinergic AgentM3 Receptor Inhibitor Umeclidinium Incruse ElliptaCYP2D6FDAActionable
TiotropiumSpiriva HandiHaler; Spiriva RespimatADRB2PharmGKBAssociative
BronchodilatorLong-Acting Beta2-Adrenergic AgonistArformoterol BrovanaCYP2D6/UGT1A1FDAActionable
Indacaterol Arcapta NeohalerUGT1A1FDAActionable
Salmeterol Serevent DiskusADRB2PharmGKBInformative
Short-Acting Beta2-Adrenergic AgonistAlbuterol ProAir; Proventil; VentolinCRHR2PharmGKBAssociative
Cystic Fibrosis Transmembrane Conductance Regulator PotentiatorCFTR Mediated Chloride Ion Transport PotentiatorIvacaftor KalydecoCFTRFDA/CPIC/ACMGActionable
Ivacaftor, Tezacaftor, and Elexacaftor TrikaftaCFTRFDA/ACMGActionable
Ivacaftor and Lumacaftor OrkambiCFTRFDA/ACMGActionable
Ivacaftor and Tezacaftor SymdekoCFTRFDA/ACMGActionable
AntitussiveN-Methyl-D-Aspartate (NMDA) Receptor AntagonistDextromethorphan Robitussin; Delsym; Pediacare; RobafenCYP2D6CPICInformative
Leukotriene Modifying AgentLeukotriene Receptor AntagonistMontelukastSingulairLTC4SPharmGKBAssociative
Rheumatology5-Aminosalicylic Acid DerivativeLocal Chemical Mediator of Inflammatory Response Modulator and TNF InhibitorSulfasalazine AzulfidineNAT2/G6PDFDAActionable
Antigout AgentOxidation of Uric Acid to Allantoin CatalystPegloticase KrystexxaG6PDFDAActionable
Urate Tubular Reabsorption InhibitorProbenecid Benemid; ProbalanG6PDFDAActionable
Xanthine Oxidase InhibitorAllopurinol ZyloprimHLA-BFDA/CPICActionable
ABCG2PharmGKBAssociative
URAT1 InhibitorLesinurad ZurampicCYP2C9FDAActionable
AntirheumaticPurine AntagonistAzathioprineAzasan; ImuranTPMT/NUDT15FDA/CPICActionable
Dihydrofolate Reductase InhibitorMethotrexate Otrexup; Rasuvo; Trexall; XatmetABCB1PharmGKBAssociative
MTHFRPharmGKBInformative
ATICPharmGKBInformative
MTRRPharmGKBAssociative
TYMSPharmGKBAssociative
SLC19A1PharmGKBInformative
Janus Associated Kinase InhibitorUpadacitinib RinvoqCYP2D6FDAActionable
CYP3A4FDAInformative
Disease ModifierTumor Necrosis Factor InhibitorEtanercept EnbrelTNFPharmGKBInformative
Monoclonal AntibodyTumor Necrosis Factor InhibitorAdalimumab HumiraTNFPharmGKBAssociative
Infliximab RemicadeTNFPharmGKBAssociative
Non-Steroidal Anti-Inflammatory DrugSelective COX-2 InhibitorCelecoxib CelebrexCYP2C9FDA/CPICActionable
LumiracoxibInternational use onlyCYP2C9CPICActionable
AceclofenacInternational use onlyCYP2C9CPICActionable
Cyclooxygenase 1 and 2 InhibitorFlurbiprofen AnsaidCYP2C9FDA/CPICActionable
Piroxicam FeldeneCYP2C9FDA/CPICActionable
Meloxicam Anjeso; Mobic; Qmiiz ODT; VivlodexCYP2C9FDA/CPICActionable
Ibuprofen Addaprin; Advil Junior Strength; Advil Migraine; Advil; Caldolor; Childrens Advil; Childrens Motrin; Dyspel; Genpril; GoodSense Ibuprofen Childrens; GoodSense Ibuprofen; IBU; Ibuprofen Childrens; Infants Advil ; KS Ibuprofen; Motrin Childrens; Motrin IB; Motrin Infants Drops; NeoProfen; ProvilCYP2C9FDA/CPICActionable
CYP2C8PharmGKBAssociative
Lornoxicam International use onlyCYP2C9CPICActionable
TenoxicamInternational use onlyCYP2C9CPICActionable
Diclofenac Diclozor; Flector; Pennsaid; Voltaren; Xrylix; Cambia; Zipsor; ZorvolexCYP2C9CPICActionable
Indomethacin Indocin; TivorbexCYP2C9CPICActionable
Naproxen Aleve; EC-Naprosyn; EC-Naproxen; GoodSense Naproxen Sodium; Mediproxen; Naprelan; Naprosyn; Naproxen DRCYP2C9CPICActionable
Nabumetone Relafen DSCYP2C9CPICActionable
Prostaglandin Synthesis and Platelet Aggregation InhibitorAspirinEcotrin; Bayer; Asctiptin; DurlazaCYP2C9CPICActionable
G6PDCPICInformative
LTC4SPharmGKBAssociative
PTGS1PharmGKBAssociative
Muscle RelaxantIntraneuronal Activity in Descending Reticular Formation and Spinal Cord SuppressantCarisoprodol Soma; VanadomCYP2C19FDAActionable
Smoking CessationSmoking Cessation AidStereo-Selective Nicotinic-Cholinergic Receptor AgonistNicotine GoodSense Nicotine; Nicoderm CQ; Nicorelief; Nicorette Mini; Nicorette Starter Kit; Nicorette; Nicotine Mini; Nicotine Step 1; Nicotine Step 2; Nicotine Step 3; Nicotrol; Nicotrol NS; ThriveCOMTPharmGKBAssociative
CHRNA5PharmGKBInformative
CYP2A6PharmGKBInformative
Dopamine and Norepinephrine Reuptake InhibitorBupropion Aplenzin; Forfivo XL; Wellbutrin SR; Wellbutrin XLCYP2B6CPIC/PharmGKBInformative
ToxicologyAntidoteMethemoglobin BinderSodium Nitrite NithiodoteG6PDFDAActionable
Heavy Metal ChelatorSuccimer ChemetG6PDFDAActionable
Dimercaprol Bal In OilG6PDCPICInformative
Opioid AnatagonistOpioid Receptor AntagonistNaltrexone VivitrolCOMT/OPRM1CPICActionable
UrologyAlpha-1 BlockerSelective Alpha-1A Adrenoceptor AntagonistTamsulosin FlomaxCYP2D6FDAActionable
CYP3A4FDAInformative
Anticholinergic AgentCompetitive Muscarinic Receptor AntagonistTolterodine DetrolCYP2D6FDAActionable
CYP3A4FDAInformative
Fesoterodine ToviazCYP2D6FDAActionable
Selective M3 Receptor AntagonistDarifenacin EnablexCYP2D6FDAActionable
Genitourinary AgentBeta-3 Adrenergic Receptor AgonistMirabegron MyrbetriqCYP2D6FDAActionable
VasodilatorPhosphodiesterase-5 Enzyme InhibitorSildenafil Viagra; RevatioGNB3PharmGKBAssociative
Analgesic AgentVoltage-Gated Sodium Channel InhibitorPhenazopyridine AZO Urinary Pain Relief; Pyridium; Urinary Pain ReliefG6PDCPICInformative
Infectious Diseases / Ophthalmology / OtorhinolaryngologyQuinoloneBacterial Topoisomerase II (DNA Gyrase) and Topoisomerase IV InhibitorCiprofloxacinCipro; Ciloxan; Cetraxal; OtiprioG6PDCPICInformative
SupplementsVitaminsFolic Acid AgonistmethylfolateDeplinMTHFRCPICInformative
Infectious Diseases / OphthalmologyQuinoloneBacterial Topoisomerase II (DNA Gyrase) and Topoisomerase IV InhibitorMoxifloxacinAvelox; Moxeza; VigamoxG6PDCPICInformative