Testing Highlights

INTRODUCTION


Innovative Gx Laboratories background

  • Specialty in Precision Molecular Diagnostics
  • Over thirty combined years of genetic laboratory research from our team of scientists
  • Central laboratory located in San Antonio, Texas with support staff throughout the U.S
  • Offering molecular services in pharmacogenomics (PGx), full infectious disease (including SARS Co-V-2 COVID-19 PCR/Rapid Antigen), and hereditary genetic disease testing
  • CLIA and COLA accredited for laboratory excellence

SARS CORONAVIRUS (COVID-19) TESTING


SARS Co-V-2 (COVID-19) Testing

  • PCR (RT PCR) SARS Co-V-2 Viral (COVID-19) Testing
  • Rapid Antigen SARS Co-V-2 Viral (COVID-19) Testing

ANTIGEN TESTING


Antigen testing examines the viral proteins on the surface of the virus and is dose dependent on the amount of virus and timing of testing/virus infection.

REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION (RT PCR) TESTING


  • Viral RNA based testing (can detect very small amounts of viral RNA)
  • Transcribes RNA into a complementary DNA strand
  • Molecular probes for specific sequences are used and areas are amplified using a fluorescent probe
  • Analysis of signal will detect viral sequences and how much virus was in the original sample
  • Over 99% accuracy of detection throughout the infection
  • Not dose dependent on amount of virus in sample

ANTIGEN VERSUS RT PCR BASED TESTING


Antigen

  • Examines the proteins on the virus.
  • Can be performed in as little as 15 minutes as a point of care test.
  • Is dose dependent (too little virus = negative result).
  • Can give false negative test results if not enough virus is present (such as early or late in the infection).

RT PCR

  • Examines the viral RNA in the virus itself.
  • Sample must be sent to the laboratory for molecular testing, IGx delivers results within 24 hours upon receipt by the laboratory.
  • Is not dose dependent (very small amount of RNA = positive result).
  • 99+% accuracy of testing results throughout the infection.

PHARMACOGENOMIC TESTING APPLICATIONS


CARDIOVASCULAR PHARMACOGENOMICS


Examples of Medications Impacted By PGx: Cardiovascular

  • Rivaroxaban (Xarelto)
  • Warfarin (Coumadin)
  • Simvastatin (Zocor)
  • Propafenone (Rythmol)
  • Clopidogrel (Plavix)
  • Atorvastatin (Lipitor)
  • Carvedilol (Coreg)
  • Hydrochlorothiazide (Lasix)
  • Spironolactone (Aldactone)
  • Metoprolol (Lopressor)

MENTAL HEALTH PHARMACOGENOMICS


Examples of Medications Impacted By PGx: Mental Health.

  • Carbamazepine (Tegretol)
  • Citalopram (Celexa)
  • Escitalopram (Lexapro)
  • Clomipramine (Anafranil)
  • Sertraline (Zoloft)
  • Amitriptyline (Elavil)
  • Venlafaxine (Effexor)
  • Nortriptyline (Pamelor)
  • Paroxetine (Paxil)
  • Fluoxetine (Prozac)

PAIN MANAGEMENT PHARMACOGENOMICS


Examples of Medications Impacted By PGx: Pain Management.

  • Carisoprodol (Soma)
  • Tramadol (Ultram)
  • Hydrocodone (Vicodin)
  • Oxycodone (Percocet)
  • Celecoxib (Celebrex)
  • Meloxicam (Mobic)
  • Diclofenac (Voltaren)
  • Methadone (Dolophine)
  • Naproxen (Aleve)
  • Codeine

HOSPITAL ORGANIZATIONS AND MEDICAL CENTERS WITH ACTIVE PHARMACOGENETIC TESTING PROGRAMS FOR PATIENTS


  • Harvard University Medical School
  • Stanford Health Care
  • St. Jude Children’s Research Hospital
  • Vanderbilt University Medical Center
  • Mayo Clinic
  • Penn Medicine
  • Duke University Medical Center
  • University of North Carolina Medical Center
  • Children’s Mercy Hospital
  • Department of Veterans Affairs
  • Brigham and Women’s Hospital

ORGANIZATIONS THAT RECOGNIZE PGX TESTING


  • American Academy of Family Physicians (AAFP)
  • American Psychiatric Associations (APA)
  • American Medical Association (AMA)
  • American Academy of Neurology (AAN)
  • American Society of Clinical Oncology (ASCO)

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